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Test Code Imip G Imipramine and Desipramine, Serum

Useful For

Monitoring imipramine and desipramine concentrations during therapy

 

Evaluating potential imipramine and desipramine toxicity

 

May aid in evaluating patient compliance

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Imipramine and Desipramine, S
Seattle Children's Hospital Note:

Clinical System Name:  Imipramine + Desipramine Group

Specimen Type

Serum Red


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (Serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Collect specimen immediately before next scheduled dose (minimum 12 hours after last dose).

2. Centrifuge and aliquot serum into a plastic vial. Serum must be separated from cells within 2 hours of collection.


Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  7 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Imipramine and Desipramine

Total therapeutic concentration: 175-300 ng/mL

 

Desipramine

Therapeutic concentration: 100-300 ng/mL

Note: Therapeutic ranges are for specimens collected at trough (ie, immediately before next scheduled dose). Levels may be elevated in non-trough specimens.

Method Description

The tricyclic antidepressants are extracted from serum using a solvent to precipitate proteins. The supernatant is removed, and analysis is by liquid chromatography tandem mass spectrometry.(Unpublished Mayo method)

Day(s) Performed

Tuesday, Thursday, Sunday

Seattle Children's Hospital Note:

TAT: 4 - 6 days

Report Available

3 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
IMIPR Imipramine and Desipramine, S 43123-9

 

Result ID Test Result Name Result LOINC Value
63508 Imipramine 3690-5
37121 Desipramine 3531-1
37122 Imipramine and Desipramine 9627-1

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Cardiovascular Test Request Form (T724)

-Therapeutics Test Request (T831)