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HelpTest Code LAB106 B-Type Natriuretic Peptide
Clinical System Name
B-type Natriuretic Peptide
Synonyms
LAB106
BNP
Brain Natriuretic Peptide
Sample Requirements
Specimen: Whole Blood
Container(s): Lavender/EDTA
Preferred Vol: 1.0 mL
Minimum Vol: 0.5 mL Microtainer; 1.0 mL Macrotainer
Notes : A Lavender top/EDTA Macrotainer must contain at least 1.0 mL.
Specimens drawn in glass tubes will be rejected.
Off site minimum volume is 2 EDTA Microtainers or 1 mL EDTA Macrotainer.
Processing Instructions
Reject due to: Insufficient Quantity, Wrong Sample Collection, Age of specimen, Specimens drawn in glass tubes.
Spin: N
Aliquot: N
Storage location: Core 5 Chemistry Refrigerator
Off-site collection: Specimen should be centrifuged within 7 hours of collection. Spin blood and transfer plasma to plastic tube and refrigerate or freeze. Method affected by prolonged exposure to RBCs.
Stability
| Specimen Type | Temperature | Time |
|---|---|---|
| EDTA Plasma | RT |
≤ 7 h |
| EDTA Plasma | 2-8 C |
≤ 24 h |
| EDTA Plasma | -20 C or -70 C |
≤ 365 d |
| Specimen Type | Temperature | Time |
|---|---|---|
| EDTA Whole Blood | RT |
≤ 7 h |
| EDTA Whole Blood | 2-8 C |
≤ 7 h |
| -20 C or -70 C | N |
Availability
| STAT | Performed | TAT |
|---|---|---|
| Y | 24/7 | 1 h |
Performing Laboratory
Seattle Children's Laboratory
Department
Department: Core Chemistry
Phone Number: 206-987-2617 (Client Services)
CPT Codes
83880
Methodology
Method: Fluorescent Immunoassay (FIA) by Triage MeterPro
Analytical Volume: 0.25 mL EDTA Whole Blood or Plasma
Reference Range
| Age | pg/mL |
| 0 - 7 d | 0 - 170 |
| > 7 d | 0 - 41 |
Description
BNP is a neurohormone synthesized primarily by ventricular cardiac myocytes. Increased plasma BNP levels have been observed in adults with congestive heart failure, ventricular hypertrophy, heart transplant rejection, and other conditions. It typically has been used as an aid in the diagnosis and assessment of severity of congestive heart failure, but studies have shown an association between heart transplant rejection and persistent elevated BNP levels, and a reduction in BNP levels with successful treatment of transplant rejection.