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HelpTest Code LAB112 Alkaline Phosphatase, Serum
Clinical System Name
Alkaline Phosphatase, Serum
Synonyms
LAB112
ALK P
Alk Phos
Phosphatase, Alkaline
Sample Requirements
Specimen: Whole Blood
Container(s): Lt. Green/Mint Top Lithium Heparin, Lt. Green/Lithium Heparin Microtainer, Gold SST, Gold Microtainer, Dark Green/Sodium Heparin, Red
Preferred Vol: 1.0 mL
Minimum Vol: 0.5 mL
Note: Test is affected by hemolysis, prolonged exposure to RBC's, EDTA, oxalate, fluoride & prolonged storage at room temperature. Hemolysis & prolonged room temp storage may result in elevated results.
Processing Instructions
Reject due to: Marked hemolysis, age of specimen
Spin: Y
Aliquot: Y
Storage location: CORE 5 Refrigerator
Off-site collection: Specimen should be centrifuged within 2 hours of collection. Spin blood, and transfer serum or plasma to plastic tube and refrigerate.
Stability
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum or Plasma | RT |
≤ 4 d |
| Serum or Plasma | 2-4 C |
≤ 4 d |
| Serum or Plasma | -20 C or -70 C |
≤ 4 d |
Availability
| STAT | Performed | TAT |
|---|---|---|
| Y | 24/7 | 1 h |
Performing Laboratory
Seattle Children's Laboratory
Department
Department: Core Lab Chemistry
Phone Number: 206-987-2617 (Client Services)
CPT Codes
84075
Methodology
Method: Spectrophotometric, Enzyme Rate by Vitros 4600
Analytical Volume: 0.02 mL + 0.03 mL dead space.
Reference Range
| Age | Male (IU/L at 37° C) | Female (IU/L at 37° C) |
| 0 - 15 d | 91 - 256 | 91 - 256 |
| 15 d - 1 y | 131 - 476 | 131 - 476 |
| 1 - 10 y | 151 - 342 | 151 - 342 |
| 10 - 13 y | 137 - 425 | 137 - 425 |
| 13 - 15 y | 124 - 474 | 66 - 262 |
| 15 - 17 y | 91 - 339 | 59 - 173 |
| 17 - 19 y | 64 - 158 | 64 - 158 |
| >19 y | 50 - 136 | 50 - 136 |
Description
Alkaline phosphatase is present mainly in kidney, bone, liver, intestine, placenta, and lung. Serum alkaline phosphatase may be elevated in increased bone metabolism; hyperparathyroidism; Paget's disease of bone; carcinoma metastatic to bone; osteogenic sarcoma; and Hodgkin's disease if bones are invaded. Hepatobiliary diseases involving cholestasis, inflammation, and cirrhosis increase alkaline phosphatase activity, as does renal infarction.