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Test Code LAB141 Uric Acid

Important Note

If the patient is receiving Rasburicase, place specimen in outside pocket of a pre-filled biohazard bag of ice, then put into a separate biohazard bag for transport. Continue to place samples on ice for 96 hours after last rasburicase dose

Clinical System Name

Uric Acid

Synonyms

URIC

LAB141

Sample Requirements

Specimen:  Whole Blood

Container(s): Lt. Green/Mint Top Lithium Heparin, Lt. Green/Lithium Heparin Microtainer, Gold SST, Gold Microtainer, Dark Green/Sodium Heparin, Red

Preferred Vol: 1.0 mL

Minimum Vol: 0.5 mL

 

Note:  Method is affected by EDTA, Sodium Fluoride, Sodium Citrate, and gross hemolysis. If the patient is receiving Rasburicase, place specimen in outside pocket of a pre-filled biohazard bag of ice, then put into a separate biohazard bag for transport. 

Processing Instructions

Reject due to: Rasburicase patient samples not arriving on ice, Insufficient quantity, incorrect specimen type, Age of specimen

Spin: Y

Aliquot: Y

Temp: 2-4oC (Rasburicase patient samples only)

Storage location: Core Chemistry Refrigerator

Notes: Specimens received on ice from Rasburicase patients should be spun in the refrigerated centrifuge and delivered to Core Cell immediately.

 

Off-site collection: Specimen should be centrifuged within 2 hours of collection. Spin blood and transfer serum or plasma to plastic tube and refrigerate or freeze.

Stability

Specimen Type Temperature Time
Serum or Plasma RT

≤ 3 d
Serum or Plasma  2-4 C

≤ 5 d
Serum or Plasma -20 C or -70 C

≤ 6 m

Availability

STAT Performed TAT
Y 24/7 1 h

Performing Laboratory

Seattle Children's Laboratory    

Department

Department:  Core Chemistry

Phone Number: 206-987-2617 (Client Services)

CPT Codes

84550

Methodology

Method: Colorimetric method by Vitros 4600

Analytical Volume:  0.01 mL + 0.03 mL dead space

Reference Range

Age mg/dL
0 - 18 y 2.0 - 6.0
Female > 18 y   2.0 - 6.0
Male > 18 y 2.0 - 7.0

Description

Uric acid is the end product of purine metabolism. Elevations of uric acid occur in renal failure, prerenal azotemia, gout, lead poisoning, excessive cell destruction (e.g., following chemotherapy), hemolytic anemia, myocardial infarction, congestive heart failure, endocrine disorders, acidosis, and glycogen storage disease type I. Low uric acid concentration may be found following treatment by some drugs (e.g., low dose aspirin), low dietary intake of purines, renal tubular defects, and in xanthinuria.