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HelpTest Code LAB1958 MPS IV Monitoring, Urine
Additional Codes
U MPS4Mon
Clinical System Name
MPS IV Monitoring, Urine
Synonyms
Keratan Sulfate, Urine
Morquio Syndrome Monitoring, Urine
Sample Requirements
Specimen: Urine
Container(s): Sterile Screw-Capped Container
Preferred Vol: 5.0 mL
Minimum Vol: 3.0 mL
Note:
Processing Instructions
Reject due to:
Spin: N
Aliquot: Y
Temp: Frozen
Storage Location: Place urine aliquot container in Send Outs freezer.
Off-site Collection: Send urine frozen.
Stability
| Specimen Type | Temperature | Time |
|---|---|---|
| Room temp | ||
| Refrigerated | ||
| Frozen | Y |
Availability
| STAT | Performed | TAT |
|---|---|---|
| N | 10 d |
Performing Laboratory
Greenwood Genetic Center
106 Gregor Mendel Circle
Greenwood, SC 29646
Phone Number: (888) 442-4363
Department
Department: Send Outs
Phone Number: (206) 987-2563
CPT Codes
83864 (x2)
Methodology
Method: Quantitative analysis of total glycosaminoglycans (GAGs) is performed using a 1,9-dimethylene blue (DMB) colorimetric reaction that is measured by spectrophotometry at a wavelength of 656 nm. GAG measurements are reported relative to the creatinine concentration in the patient's urine.
Quantification of individual glycosaminoglycans -chondroitin sulfate (uCS), dermatan sulfate (uDS), heparan sulfate (uHS), and keratan sulfate (uKS)- is performed using liquid chromatography-tandem mass spectrometry.
Analytical Volume: 3.0 mL Random Urine
Limitations:
Reference Range
| Total GAGs | 0 - 16 mg/mmol Creatinine |
| Chondroitin Sulfate | 0 - 11.21 g/mol Creatinine |
| Keratan Sulfate | 0 - 9.6 mcg/mg Creatinine |
Send Out Instructions
| Reference Test Name: |
Mucopolysaccharidosis IV (MPSIV), Morquio syndrome: Urine Monitoring (Total GAGs, KS, CS) |
| Reference Lab Test Code: | MPS IV (Total GAGs, KS, CS) |
| Instructions: |
Ship frozen samples overnight via FedEx to Greenwood Genetics. Saturday deliveries are accepted. |