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Test Code LAB2418 CSF Glucose + Protein

Important Note

Simultaneous blood glucose levels are recommended.

Clinical System Name

CSF Glucose + Protein

Synonyms

LAB2418

CHEM CSF

Sample Requirements

Specimen: CSF

Container(s):  CSF Tube, Sterile Screw-Capped Container, Sterile Screw-Capped Tube, Syringe

Preferred Vol: 1.0 mL

Minimum Vol: 0.5 mL

Note: Note collection type on requisition and container (e.g. "LP" for CSF lumbar puncture.) Send to the lab immediately (within 1 hour) for accurate results.

Processing Instructions

Reject due to: Age of Specimen (give to Core Lab for determination)

Spin: Y

Aliquot: Y

Storage location:  Core 5 Chemistry Refrigerator

 

Off-site collection: Simultaneous blood glucose levels are recommended. Specimen should be centrifuged within 1 hour of collection. Spin CSF and transfer supernatant to sterile plastic tube and refrigerate or freeze.

Stability

Specimen Type Temperature Time
CSF RT

≤ 4 h
CSF 2-8 C

≤ 3 d
CSF -20 C or -70 C

≤ 180 d

Availability

STAT Performed TAT
Y 24/7 1 h

Performing Laboratory

Seattle Children's Laboratory    

Department

Department:  Core Chemistry

Phone Number: 206-987-2617 (Client Services)

CPT Codes

82945

84157

Methodology

Method:  Colorimetric method by Vitros 4600

Analytical Volume:  0.02 mL + 0.03 mL dead space

Reference Range

Normal CSF glucose is 45 - 60% of serum glucose measured at the same time.
 

CSF PROTEIN:

Age mG/dL
< 1 m Up to 120
1 - 3 m Up to 75
3 m - adult   Up to 40

Description

CSF glucose may be done to diagnose tumors, infections, inflammation of the central nervous system, delirium, and other neurological and medical conditions.

 

Diseases that interrupt the integrity of the capillary endothelial barrier can lead to an increase in total CSF protein. CSF protein is generally increased in all types of meningitis, cerebral infarction, brain abscess, meningovascular syphilis, subarachnoid hemorrhage, some brain tumors, trauma to the brain, some cases of multiple sclerosis, encephalomyelitis, and degenerative neurologic diseases. A decreased CSF protein may occur in water intoxication, CSF leak (CSF rhinorrhea or otorrhea), and hyperthyroidism.