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HelpTest Code LAB2793 Cyclic Citrullinated Peptide (CCP) Antibodies
Clinical System Name
Cyclic Citrullinated Peptide (CCP) Antibodies
Synonyms
Anti CCP
Anti Cyclic Citrullinated Peptide
CCP Antibody
Cyclic Citrullinated Peptide Antibody
Rheumatoid Arthritis Antibody
CCP
Sample Requirements
Specimen: Whole Blood
Container(s): Gold SST, Red, Lavender/EDTA
Preferred Vol: 2.0 mL
Minimum Vol: 1.0 mL
Note:
Processing Instructions
Reject due to:
Spin: Y
Aliquot: Y
Temp: 2-8 C
Storage location: Spin blood, transfer 1 mL serum to a plastic aliquot tube affixed with a large computer label. Refrigerate in CPA FrigF rack.
Off-site collection: Spin blood, transfer serum to a plastic aliquot container. Ship refrigerated.
Stability
| Specimen Type | Temperature | Time |
|---|---|---|
| After separation from cells/serum separator | Room temp | |
| Refrigerated | 7 d | |
| Frozen | 1 m |
Availability
| STAT | Performed | TAT |
|---|---|---|
| N | M-F | 1-3 d |
Performing Laboratory
Seattle Children's Laboratory
Department
Department: Chemistry
Location: Chem East
Phone Number: (206) 987-2617
CPT Codes
86200
Methodology
Method: None Immunoassay on Bioplex 2200
Analytical Volume: 0.4 mL
Limitations:
Reference Range
| U/mL | |
| Non-reactive | <3.0 |
| Reactive | > 3.0 |
Because of differences between assays from different manufacturers, all results include this comment: "The following results were obtained with the Bioplex 2200 Anti-CCP IgG assay. Results obtained from other manufacturers' assay methods may not be used interchangeably."
Description
This test is used in the evaluation of patients suspected of having juvenile rheumatoid arthritis or other connective tissue diseases that may present with arthritis. It is used to detect citrullinated antibodies in patient serum or plasma. Citrullin is an unusual amino acid formed after post-translational modification to arginine.
Results are obtained using the Bioplex 2200 Anti-CCP IgG assay. In this method, anti-CCP results > 3 U/mL are considered reactive. Results obtained from other manufacturers’ assay methods should not be used interchangeably.