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Test Code LAB2937 CoEnzyme Q10 Level, Leukocytes

Additional Codes

WBC CoQ10

Clinical System Name

CoEnzyme Q10 Level, Leukocytes

Synonyms

Leukocyte, Intracellular Coenzyme Q10; Ubiquinone
 

Sample Requirements

Specimen: Whole Blood

Container(s): Yellow/ACD A or B

Preferred Vol: 5.0 mL

Minimum Vol: 2.0 mL

 

Notes: An ACD tube can be obtained from the Main Lab. The collection tube can be either ACD solution A or ACD solution B; both are acceptable.

Processing Instructions

Reject due to: Hemolyzed sample; Incorrect collection tube (Gold SST); Received frozen

Spin: N

Aliquot: N

Temp: 2 - 8 C

Storage Location: Affix a large Epic label to the sample(s) and place in CPA1 refrigerator Send Outs rack.

 

Off-site Collection: Send whole blood refrigerated.

Stability

Specimen Type Temperature Time
Whole Blood Room Temp 5 d
  Refrigerated 5 d
  Frozen Unacceptable

Availability

STAT Performed TAT
N    10 - 14 d

 

Performing Laboratory

Medical Neurogenetics (MNG) Laboratories

5424 Glenridge Drive NE

Atlanta, GA 30342

 

Phone: (678) 225-0222

Department

Department: Send Outs

Phone: (206) 987-2563

CPT Codes

82542

Methodology

Method: HPLC/Electrochemistry

Analytical Volume: 2.0 mL Whole Blood

Limitations:

Reference Range

Interpretive report is provided.

Send Out Instructions

Reference Test Name: Coenzyme Q10 (Leukocytes)
Reference Lab Test Code: MET04
Instructions: Ship on an ice pack via FedEx Priority Overnight. Saturday deliveries are accepted.

 

Description

Coenzyme Q10 is produced by the body and is necessary for basic cell functioning. Deficiencies in coenzyme Q10 can be primary or secondary. Primary coenzyme Q10 deficiency is a rare autosomal recessive genetic condition with clinically heterogeneous presentation that can include:

  •     encephalopathy
  •     seizures
  •     ataxia
  •     cardiomyopathy
  •     renal failure
  •     cerebellar atrophy
  •     Leigh Syndrome
  •     growth retardation
  •     delayed motor development
  •     lactic acidemia
  •     hypergonadotropic hypogonadism/myopathy

These individuals will have decreased levels of coenzyme Q10 in plasma as well as in skeletal muscle. Secondary coenzyme Q10 deficiency has been seen in individuals with several chronic disorders such as heart conditions, muscular dystrophies, and mitochondrial disorders (such as MELAS and Kearns-Sayre). Additionally, some prescription drugs can lead to a decrease in coenzyme Q10 levels.