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Test Code LAB2969 Cystine, WBC

Important Note

This is a time sensitive draw. Samples must be collected M - Th, 09:00 AM to 14:00 PM in order to ship same day. Specimens should also be placed on ice or a cold pack, immediately.

Note: If this testing is being drawn at a Seattle Children's Regional Clinic, please notify the Send Outs department (ext. 7-2563) or Laboratory Client Services (ext. 7-2617). Regional Clinic collections must occur M - Th, 09:00 AM to 11:00 AM. The sample must be sent DIRECT via Delivery Express to Seattle Children's Main Lab.

Additional Codes

Leuk Cyst

Clinical System Name

Cystine, WBC

Synonyms

WBC Intracellular Cystine Assay

Sample Requirements

Specimen: Whole Blood

Container(s): Yellow Top/ACD-Solution A

Preferred Vol: 5.0 - 10.0 mL

Minimum Vol: 2.0 mL

 

Notes: Test is used for initial diagnosis and for monitoring. This is a time sensitive draw for monitoring: Patients on Cystagon are collected 5-6 hours after their last dose. Patients on Procysbi should have sample collected right before their dose. Note drug, time of last dose on requisition, place whole blood in cold pack and transport to CPA.

Processing Instructions

Reject due to: any tube other than Yellow Top/ACD-Solution A

Spin: N

Aliquot: N

Temp: 2 - 8 C

Storage Location: Place whole blood on cold pack or on ice immediately and transport to CPA. Refrigerate within ONE hour. Note drug (Cystagon or Procysbi) and time of last dose on requisition.

 

Off-site collection: No off-site collection.

Stability

Specimen Type Temperature Time
Whole Blood Refrigerated 24 hr

Availability

STAT Available TAT
N   21 d

Performing Laboratory

UCSD Medical Center

Biochemical Genetics Laboratory

CTF Bldg, Room B-213

212 Dickinson Street

San Diego, CA 92103

 

Phone Number: (619) 543-5260

Department

Department: Send Outs

Phone Number: (206) 987-2563

Methodology

Method:

Analytical Volume: > 2.0 mL Whole Blood

Limitations:

Reference Range

Interpretive report is provided.

Send Out Instructions

Reference Test Name: WBC Intracellular Cystine Assay
Reference Test Number: None specified
Instructions: Ship whole blood refrigerated via FedEx Priority Overnight, Monday through Thursday. UCSD's Cystine Determination Laboratory does not accept Saturday delivery.

 

Special Instructions

Links to:

UCSD Biochemical Genetics/Cystine Lab

 

UCSD Biochemical Genetics Requisition Form

 

Extraction technique:

http://cystinosiscentral.org/tests/

Clinical Utility

GeneReviews: Cystinosis

 

Nephropathic cystinosis in untreated children is characterized by renal tubular Fanconi syndrome, poor growth, hypophosphatemic rickets, impaired glomerular function resulting in complete glomerular failure, and accumulation of cystine crystals in almost all cells, leading to cellular destruction and tissue dysfunction.  Cystinosis is inherited in an autosomal recessive manner.