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Test Code LAB3035 Factor 8 Inversion DNA

Additional Codes

F8 Inversion

Clinical System Name

Factor 8 Inversion DNA


Bloodworks Northwest F8 Inversion; DNA Factor VIII Inversion; Intron 1 or 22 Inversion

Sample Requirements

Preferred Specimen: Whole Blood

Container(s): Lavender/EDTA

Preferred Vol: 10.0 mL

Minimum Vol: 5.0 mL


Alternative Specimen: DNA

Container(s): Sterile plastic tube

Preferred Vol: 10 µg of purified DNA at a concentration of at least 50 µg/ml

Minimum Vol: 5 µg of purified DNA at minimum concentration of 50 µg/ml


Alternative Specimen (e.g. salvia or buccal): Not accepted


Note:BWNW Hemostasis Requisition must be completed and accompany specimen to lab. Send tubes to lab immediately.


Whole blood shipped at 2-8 C or ambient temperature is acceptable and should arrive in the lab within 48 hours.


Processing Instructions

Reject due to:

Spin: N

Aliquot: N

Temp: RT

Storage location: Give whole blood to Send Outs.


STAT Performed TAT
N Daily 5-10 d


Performing Laboratory

Bloodworks Northwest

Hemostasis Reference Laboratory
921 Terry Ave
Seattle WA 98104

Phone: (206) 689-6594



Department: Send Outs

Phone: (206) 987-2563

Reference Range

Interpretive report provided.


Method: Polymerase Chain Reaction (PCR) Based

Analytical Volume: 5.0 mL Whole Blood

Clinical Utility

In severe hemophilia A, a common recurrent intron 22 gene inversion accounts for ~45% of the cases. A recurrent intron 1 inversion accounts for ~5% of the cases. These two sites are the first to be screened for severe hemophilia A patients.

Send Out Instructions

Reference Test Name: DNA Factor VIII Inversion
Reference Lab Test Code: 3250-05
Instructions: Send sample and requisition to BWNW via Delivery Express courier. Needs to be delivered to BWNW within 48 hours of collection.