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HelpTest Code LAB3044 Fanconi Anemia Breakage Study
Clinical System Name
Fanconi Anemia Breakage Study
Synonyms
Breakage Study; CH-BKST; DEB Test; Fanconi Anemia; Mutagen Stress Test
Description
Useful for the differential diagnosis between idiopathic aplastic anemia and Fanconi anemia. After treatment with similar doses of bifunctional alkylating agents such as Diepoxybutane (DEB) or Mitomycin C (MMC), Fanconi anemia patients will typically show a greater than 50-fold increase in rates of chromosome breakage compared to concurrent controls or other aplastic anemia patients.
Sample Requirements
Specimen: Whole Blood
Container(s): DARK GREEN NaHep
Preferred Vol: 5.0 mL
Minimum Vol: 3.0 mL
Note: Do not use gel separator tubes or lithium heparin tubes (i.e. no microtainers). Draw samples Monday - Friday 7AM - 1330 PM ONLY. Keep sample at room temperature; deliver promptly to the Main Lab.
Processing Instructions
Reject due to: Clotted or frozen specimen.
Spin: N
Aliquot:N
Temp: RT
Storage location: Keep sample at room temperature. Store specimen and labels in the Send Outs room temperature box in CPA. Notify Send Outs immediately.
Off-site collection: Keep sample at room temperature. Deliver promptly to lab.
Stability
| Specimen Type | Temperature | Time |
|---|---|---|
| Whole Blood | Room temp | 24 h |
| Refrigerated | ||
| Frozen |
Availability
| STAT | Performed | TAT |
|---|---|---|
| N | Processed daily | 7 - 14 d |
Performing Laboratory
M Health Fairview
UMMC East Bank
500 Harvard St. SE, Room 3-580
Minneapolis, MN, 55455
Phone Number: (612) 273-3171
Department
Department: Send Outs
Phone: (206) 987-2563
Reference Range
Interpretive report provided.
Methodology
Method: Determined by laboratory director based on clinical information. Chromosome breakage analysis.
Analytical Volume: None specified
Limitations:
Clinical Utility
Useful for the differential diagnosis between idiopathic aplastic anemia and Fanconi anemia. After treatment with similar doses of bifunctional alkylating agents such as Diepoxybutane (DEB) or Mitomycin C (MMC), Fanconi anemia patients will typically show a greater than 50-fold increase in rates of chromosome breakage compared to concurrent controls or other aplastic anemia patients.
Send Out Instructions
| Reference Test Name: |
Chromosome Analysis, Blood, Fanconi Mutagen Sensitivity |
| Reference Lab Test Code: | |
| Instructions |
Ship Monday through Friday via FedEx Priority Overnight. Saturday deliveries are accepted. |