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HelpTest Code LAB3282 Metanephrines, Fractionated, Free, Plasma
Additional Codes
METANEP PL
Reporting Name
Metanephrines, Fract., Free, PSCH Clinical System Name: Metanephrines, Fractionated, Free, Plasma
Useful For
Screening test for presumptive diagnosis of catecholamine-secreting pheochromocytomas or paragangliomas
Specimen Required
Patient Preparation: Use of an Epi-pen within the last 7 days may produce inaccurate results.
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Within 2 hours of collection centrifuge and aliquot plasma into a plastic vial.
Collect 2.0 mL whole blood in a Lavender top.
Spin and aliquot 1 mL plasma.
Specimen Type
Plasma EDTASpecimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma EDTA | Frozen (preferred) | 28 days | |
| Refrigerated | 14 days | ||
| Ambient | 7 days |
Day(s) Performed
Monday through Saturday
TAT: 4 - 6 days
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Method Description
Free metanephrine (MN) and normetanephrine (NMN) are extracted from plasma using solid phase extraction. The concentrated eluate is analyzed using liquid chromatography tandem mass spectrometry and quantified using stable isotope labeled internal standards, d3-MN and d3-NMN . Analytes and internal standards are ionized using electro spray ionization and are detected in the multiple reaction-monitoring mode. The specific transitions for MN, NMN, d3-MN, and d3-NMN are m/z 180.2 to m/z 148.2, 166.2 to m/z 134.2, 183.2 to m/z 151.2, and m/z 169.2 to m/z 137.2, respectively.(Unpublished Mayo method)
Reference Values
METANEPHRINE, FREE
<0.50 nmol/L
NORMETANEPHRINE, FREE
<0.90 nmol/L
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83835
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PMET | Metanephrines, Fract., Free, P | 57772-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 10140 | Normetanephrine, Free | 40851-8 |
| 10139 | Metanephrine, Free | 49700-8 |
Report Available
2 to 5 daysReject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-General Request (T239)
-Oncology Test Request (T729)
Aliases: Fractionated metanephrines +; Free Metanephrine; Metanephrines free, plasma; NMN (Normetanephrines), plasma; Normetanephrine, (NMN), free; Normetanephrines, plasma