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Test Code LAB3345 Neuroblastoma Loss of Heterozygosity

Important Note

Tumor sample collected during or after the treatment (e.g. post-chemotherapy) CANNOT be accepted. However, pre-treatment relapse tumor samples will be accepted.


Exclude from UM database.

Clinical System Name

Neuroblastoma Loss of Heterozygosity


Neuroblastoma LOH

Sample Requirements

Specimen: Tumor

Container(s): Sterile Screw-Capped Container

Preferred Vol: 0.05 g of snap‐frozen tumor tissue is preferred.

Alternative: OCT‐embedded or paraffin embedded tumor tissue is also accepted.


Note: Please note, at least 40% tumor (based on internal pathology review) must
be present in the submitted sample.

Processing Instructions

Reject due to: Delayed or improper handling; Insufficient tumor content in tumor sample; Inadequate tissue; Tissue degradation; Wrong type of specimen

Spin: N

Aliquot: N

Temp: -70 C for Tumor Biopsy

Storage Location: Deliver tumor biopsy to the CPA -70 freezer, Send Outs rack.


Off-site collection:


Specimen Type Temperature Time
Paraffin Block Room Temp 6 m
Tissue Scrolls (FFPE) Room Temp 6 m
Tumor Room Temp Unacceptable
  Refrigerated Unacceptable
  Frozen 24 h



STAT Performed TAT
N Monday to Friday 4 w


Performing Laboratory

Nationwide Children's Hospital

Nationwide Children's Laboratory Services
700 Children’s Drive, Room C1955
Columbus, OH 43205


Phone Number:

Laboratory Client Services
 (614) 722-5477


Department: Send Outs

Phone Number: (206) 987-2563


This array evaluates for the following clinically significant aberrations within the cancer genome for Neuroblastoma:

  • Losses of 1p, 3p, 4p and 11q
  • Gains of 1q, 2p and 17q
  • Loss of Heterozygosity involving 1p, 3p, 4p and 11q
  • Gains of whole chromosomes will also be detected with the assay.

Information regarding other chromosome regions will not be reported, as their clinical significance in neuroblastoma is currently unknown

Reference Range

Interpretive report is provided

Send Out Instructions

Reference Test Name: Targeted Oncology Microarray
Reference Test Number: TONCMA
Instructions: Ship tumor on dry ice via FedEx Priority Overnight (Priority Plus shipping). 


Special Instructions

Nationwide Children's