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Test Code LAB3558 Wilm's Tumor Loss of Heterozygosity

Important Note

Tumor sample collected during or after the treatment (e.g. post-chemotherapy) CANNOT be accepted. However, pre-treatment relapse tumor samples will be accepted.


Exclude from UM database.

Additional Codes

Wilm's Tumor LOH

Clinical System Name

Wilm's Tumor Loss of Heterozygosity


Wilm's Tumor LOH

Sample Requirements

Specimen: Tumor

Container(s): Sterile Screw-Capped Container

Preferred Vol: 0.05 g of snap‐frozen tumor tissue is preferred.

Alternative: OCT‐embedded or paraffin embedded tumor tissue is also accepted.


Note: Please note, at least 40% tumor (based on internal pathology review) must
be present in the submitted sample.

Processing Instructions

Reject due to: Delayed or improper handling; Insufficient tumor content in tumor sample; Inadequate tissue; Tissue degradation; Wrong type of specimen

Spin: N

Aliquot: N

Temp: -70 C for Tumor Biopsy

Storage Location: Deliver tumor biopsy to the CPA -70 freezer, Send Outs rack.


Off-site collection:


Specimen Type Temperature Time
Paraffin Block Room Temp 6 m
Tissue Scrolls (FFPE) Room Temp 6 m
Tissue (Snap-frozen) Room Temp Unacceptable
  Refrigerated Unacceptable
  Frozen 24 h



STAT Performed TAT
N M - F 4 w


Performing Laboratory

Nationwide Children's Hospital

Nationwide Children's Laboratory Services
700 Children’s Drive, Room C1955
Columbus, OH 43205


Laboratory Client Services
 (614) 722-5477


Department: Send Outs

Phone Number: (206) 987-2563


Method: Microarray Analysis

This array evaluates for the following clinically significant aberrations within the cancer genome for Wilms Tumor:

  • Losses of 1p and 16q
  • Gains of 1q
  • Loss of Heterozygosity involving 1p and 16q

Information regarding other chromosome regions will not be reported, as their clinical significance in Wilms tumor is currently unknown.

Reference Range

Interpretive report is provided

Send Out Instructions

Reference Test Name: Targeted Oncology Microarray Analysis
Reference Test Number: TONCMA

Ship tumor on dry ice via FedEx Priority Overnight (Priority Plus shipping). 

Special Instructions

Nationwide Children's



*Normal/control sample required