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HelpTest Code LAB3722 Alpha Hemoglobin Common Deletions
Additional Codes
Alpha Globin
Clinical System Name
Alpha Hemoglobin Common Deletions
Synonyms
α Thalassemia
Alpha Globin
HBA1
HBA2
Alpha Globin
Description
Deletion analysis of six of the most common deletions in HBA1 and HBA2 to analyze genetic causes of Alpha-Thalassemia.
Sample Requirements
Specimen: Whole Blood
Container(s): Lavender/EDTA
Preferred Vol: 2.0 mL
Minimum Vol: 1.0 mL
Specimen: DNA
Container(s): Sterile plastic tube
Preferred Vol: 20-30 ul of 100ng/ul concentration
Alternative Specimen (e.g. saliva/bucal): Not accepted at this time. UW not validated for saliva or buccal for this testing.
Note: Yellow top ACD tubes also acceptable. Buccal cells are acceptable for transplant patients. For other specimen types contact the UW Genetics Lab (206-598-6429).
Processing Instructions
Reject due to: Heparinized sample or Formalin-fixed paraffin-embedded tissues
Spin: N
Aliquot: N
Temp: 2 - 8 C
Storage Location: Do not spin or separate specimen. Store whole blood affixed with a large Epic label in the CPA refrigerator, Send Outs rack.
Off-site Collection: Do not spin or separate specimen. Transport refrigerated.
Stability
| Specimen Type | Temperature | Time |
|---|---|---|
| Whole Blood | Room temp | 3 d |
| Refrigerated | 7 d | |
| Frozen | N | |
| Extracted DNA | Room temp | 3 - 4 d |
| Refrigerated | 1 y | |
| Frozen | Indefinitely |
Availability
| STAT | Performed | TAT |
|---|---|---|
| N | Weekly | 1 - 2 w |
Performing Laboratory
University of Washington Genetics and Solid Tumors Laboratory (UW GSTL)
Department of Laboratory Medicine
Genetics Lab
1959 NE Pacific Street, Room NW220
Seattle, WA 98195
Phone Number: (206) 520-4600
Department
Department: Send Outs/Genetic
Phone Number: (206) 987-2563
Methodology
PCR (polymerase chain reaction) with electrophoresis
Reference Range
Interpretive report provided.
Clinical Utility
A genetic diagnosis may have implications for treatment, management, recurrence risk, and family member testing.
Send Out Instructions
| Reference Test Name: | Alpha-Globin Gene Analysis |
| Reference Lab Test Code: | AGGA |
| Instructions: | Send out Monday through Friday with the UW courier. |