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HelpTest Code LAB3843 Lipoprotein Metabolism Profile, Serum
Reporting Name
Lipoprotein Metabolism ProfileSCH Clinical System Name: Lipoprotein Metabolism Profile
Useful For
Diagnosing dyslipoproteinemia
Quantifying cholesterol and triglycerides in very-low-density lipoprotein, low-density lipoprotein (LDL), high-density lipoproteins (HDL), and chylomicrons
Identifying lipoprotein-X
Classifying hyperlipoproteinemias (lipoprotein phenotyping)
Evaluating patients with abnormal lipid values (cholesterol, triglyceride, HDL, LDL) for specific phenotypes
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| TCS | Cholesterol, Total, CDC, S | No | Yes |
| TRIGC | Triglycerides, CDC, S | No | Yes |
| APLBS | Apolipoprotein B, S | Yes, (order APOLB) | Yes |
| HDLS | HDL Cholesterol, CDC, S | No | Yes |
| LMPP1 | Lipoprotein Metabolism Profile 1 | No | Yes |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumNecessary Information
Patient's age and sex are required.
Specimen Required
Patient Preparation:
1. Fasting-overnight (12-14 hours)
2. Patient must not consume any alcohol for 24 hours before the specimen is collected.
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 7 days | |
| Frozen | 60 days |
Reference Values
|
2-9 years |
10-17 years |
≥18 years |
|
|
Total cholesterol |
* Acceptable: <170 mg/dL Borderline high: 170-199 mg/dL High: ≥200 mg/dL |
** Desirable: <200 mg/dL Borderline high: 200-239 mg/dL High: ≥ 240 mg/dL |
|
|
Triglycerides |
* Acceptable: <75 mg/dL Borderline high: 75-99 mg/dL High: ≥100 mg/dL |
* Acceptable: <90 mg/dL Borderline high: 90-129 mg/dL High: ≥130 mg/dL |
** Normal: <150 mg/dL Borderline high: 150-199 mg/dL High: 200-499 mg/dL Very high: ≥500 mg/dL |
|
Low-density lipoprotein (LDL) cholesterol |
* Acceptable: <110 mg/dL Borderline high: 110-129 mg/dL High: ≥130 mg/dL |
*** Desirable: <100 mg/dL Above Desirable: 100-129 mg/dL Borderline high: 130-159 mg/dL High: 160-189 mg/dL Very high: ≥190 mg/dL |
|
|
LDL triglycerides |
≤50 mg/dL |
≤50 mg/dL |
|
|
Apolipoprotein B |
* Acceptable: <90 mg/dL Borderline high: 90-109 mg/dL High: ≥110 mg/dL |
*** Desirable: <90 mg/dL Above Desirable: 90-99mg/dL Borderline high: 100-119 mg/dL High: 120-139 mg/dL Very high: ≥140 mg/dL |
|
|
High-density lipoprotein (HDL) cholesterol |
* Low: <40 mg/dL Borderline low: 40-45 mg/dL Acceptable: >45 mg/dL |
*** Males: ≥40mg/dL Females: ≥50mg/dL |
|
|
Very low-density lipoprotein (VLDL) cholesterol |
<30 mg/dL |
<30 mg/dL |
|
|
VLDL triglycerides |
<90 mg/dL |
<120 mg/dL |
|
|
Beta VLDL cholesterol |
<15 mg/dL |
<15 mg/dL |
|
|
Beta VLDL triglycerides |
<15 mg/dL |
<15 mg/dL |
|
|
Chylomicron cholesterol |
Undetectable |
Undetectable |
|
|
Chylomicron triglycerides |
Undetectable |
Undetectable |
|
|
Lp(a) cholesterol |
<5 mg/dL |
<5 mg/dL |
|
|
LpX |
Undetectable |
Undetectable |
|
Reference values have not been established for patients who are less than 2 years of age.
*Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents
**National Cholesterol Education Program (NCEP)
***National Lipid Association
Day(s) Performed
Monday through Thursday, Sunday
CPT Code Information
80061-Lipid panel (includes: HDL [CPT Code 83718], total cholesterol [CPT Code 82465], and triglycerides [CPT Code 84478] if all performed)
82172-Apolipoprotein B
83700-Lp(a) cholesterol electrophoresis
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| LMPP | Lipoprotein Metabolism Profile | In Process |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| TCS | Cholesterol, Total, CDC, S | 2093-3 |
| HDLS | HDL Cholesterol, CDC, S | 2085-9 |
| TRIGC | Triglycerides, CDC, S | 2571-8 |
| APLBS | Apolipoprotein B, S | 1884-6 |
| 2839 | LDL Cholesterol | 2089-1 |
| 2840 | LDL Triglycerides | 3046-0 |
| 2844 | VLDL cholesterol | 2091-7 |
| 2847 | VLDL triglycerides | 3047-8 |
| 2842 | Beta VLDL Cholesterol | 66499-5 |
| 2843 | Beta VLDL triglycerides | 3045-2 |
| 2855 | Chylomicron cholesterol | 34467-1 |
| 2856 | Chylomicron triglycerides | 35363-1 |
| 2849 | Lp(a) Cholesterol | 35388-8 |
| 23924 | LpX | 42178-4 |
| 23937 | Interpretation | 59462-2 |
Method Description
Electrophoretic separation of lipoproteins followed by lipid staining and densitometry measurement.(Package insert: SPIFE Vis Cholesterol Reagent. Helena Laboratories; 09/2015
Cholesterol:
Cholesterol esters are cleaved by the action of cholesterol esterase to yield free cholesterol and fatty acids. Cholesterol oxidase then catalyzes the oxidation of cholesterol to cholest-4-en-3-one and hydrogen peroxide. In the presence of peroxidase, the hydrogen peroxide formed effects the oxidative coupling of phenol and 4-aminophenazone to form a red quinone-imine dye. The color intensity of the dye formed is directly proportional to the cholesterol concentration. It is determined by measuring the increase in absorbance (Package insert: Cholesterol Gen2 Reagent. Roche Diagnostics; V 13.0, 02/2019)
Triglyceride:
Samples analyzed for triglycerides are measured by an automated enzymatic method. The chemistry includes hydrolysis of the triglycerides and phosphorylation of the resulting glycerol.(Package insert: Triglycerides Reagent, Roche Diagnostics; 11/2017)
Apolipoprotein B:
Anti-apolipoprotein B antibodies react with the antigen in the sample to form antigen:antibody complexes, which, following agglutination, can be measured turbidimetrically.(Package insert: Tina-quant Apolipoprotein B. Roche Diagnostics; 07/2020)
High-Density Lipoprotein:
Sample is combined with dextran sulfate and magnesium, ions precipitate the low-density lipoprotein and very-low-density lipoprotein fractions, leaving the high-density lipoprotein (HDL) fraction in solution. The HDL cholesterol is then determined using an enzymatic cholesterol assay.(Package insert: HDL Cholesterol Precipitating Reagent Set (Dextran Sulfate). Pointe Scientific, INC; 12/2009)
Report Available
2 to 4 daysReject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | Reject |
Method Name
TCS, TRIGD: Enzymatic Colorimetric
APLBS: Automated Turbidimetric Immunoassay
HDLS: Selective Precipitation, Enzymatic Colorimetric
LMPP1: Ultracentrifugation/Electrophoresis/Automated Enzymatic/Colorimetric Analysis
Test Classification
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.Forms
If not ordering electronically, complete, print, and send a Cardiovascular Test Request Form (T724) with the specimen.