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HelpTest Code LAB3851 Matrix Metalloproteinase 7 (MMP-7)
Additional Codes
MMP-7
Clinical System Name
Matrix Metalloproteinase 7 (MMP-7)
Synonyms
MMP7
Sample Requirements
Specimen: Whole Blood
Container(s): Gold, Gold Microtainer, or Red Top-Plain
Preferred Vol: 4.0 mL
Minimum Vol: 2.0 mL
Processing Instructions
Reject due to: Thawed samples, plasma samples
Spin: Y
Aliquot: Y
Temp: -20 C
Storage Location: Store the aliquot in the CPA -20 freezer, Send Outs rack.
Off-site Collection: Place specimen on wet ice after collection and deliver to lab immediately. Separate from cells ASAP or within two hours of collection. Transfer 2.0 mL Serum (Min. 1.0 mL) to a plastic aliquot tube.
Stability
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Room Temp | Unacceptable |
| Refrigerated | Unacceptable | |
| Frozen | Indefinite |
Availability
| STAT | Performed | TAT |
|---|---|---|
| N | M, W, F | 5 - 8 d |
Performing Laboratory
Children's Medical Center-Dallas
1935 Medical District Dr.
Dallas, TX 75235
Phone Number: (214) 456-2320, Option 1
Department
Department: Send Outs
Phone Number: (206) 987-2563
Methodology
Method: ELISA
Analytical Volume: 1.0 mL Serum
Limitations:
Reference Range
3.6-10.5 ng/mL
Interpretive Data:
< 17 ng/mL - 95% sensitivity, 97% negative predictive value. Below 17 ng/mL, the chance is 95% that biliary atresia will not be present.
17-68 ng/mL - indeterminate. Differential in this range would include biliary atresia, but also things like indeterminate cholestasis, choledocal cyst, alpha-1-antitrypsin deficiency.
>68 ng/mL - 95% specificity, 69% positive predictive value. Above 68 ng/mL, the likelihood of biliary atresia is 95%
Caution should be exercised in the interpretation of any assay for MMP-7, and the results should be considered in conjunction with the patient’s clinical condition. High MMP-7 have been detected in premature babies and young infants with cardiovascular and/ or multi-system disease. The final diagnosis of biliary atresia requires intraoperative cholangiography and the histological presence of obstruction of the extrahepatic bile duct. The normal values of MMP-7 in premature babies have not yet been established. Clinical correlation is particularly important in premature babies.
Send Out Instructions
| Reference Test Name: | MMP-7 Matrix Metalloproteinase 7 |
| Reference Lab Test Code: | MMP-7 |
| Instructions: | Send out Monday through Thursday via FedEx Priority Overnight. |