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HelpTest Code LAB447 Delta-8 and Delta-9-Carboxy-Tetrahydrocannabinol (THC) Confirmation, Random, Urine
Reporting Name
Carboxy-THC Confirmation, USCH Clinical System Name: Urine THC Quantitation
Useful For
Detection and confirmation of drug use of cannabis/marijuana and to specifically identify and quantify delta-8-carboxy tetrahydrocannabinol (THC-COOH) and delta-9-THC-COOH
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
UrineOrdering Guidance
For situations where chain of custody is required, a Chain-of-Custody Kit (T282) is available. For chain-of-custody testing, order THCX / Delta-8 and Delta-9-Carboxy-Tetrahydrocannabinol (THC) Confirmation, Chain of Custody, Random, Urine
Additional drug panels and specific requests are available. Call 800-533-1710 or 507-266-5700.
Additional Testing Requirements
If urine creatinine is required or adulteration of the sample is suspected, order, ADULT / Adulterants Survey, Random, Urine.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container Tube: Plastic urine container
Submission Container/Tube: Plastic, 5-mL tube
Specimen Volume: 3 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative.
Additional Information:
1. No specimen substitutions.
2. STAT requests are not accepted for this test.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days | ||
| Ambient | 72 hours |
Reference Values
Not Detected
Cutoff concentration:
DELTA-8 CARBOXY-TETRAHYDROCANNABINOL (THC) by LC-MS/MS: <5.0 ng/mL
DELTA-9 CARBOXY-TETRAHYDROCANNABINOL (THC) by LC-MS/MS: <5.0 ng/mL
Day(s) Performed
Monday through Friday
TAT: 4 - 6 days
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80349
G0480 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| THCU | Carboxy-THC Confirmation, U | 20521-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 618770 | Delta-8 Carboxy-Tetrahydrocannabinol by LC-MS/MS | 20521-1 |
| 2497 | Delta-9 Carboxy-Tetrahydrocannabinol by LC-MS/MS | 20521-1 |
| 21186 | Carboxy-THC Interpretation | 69050-3 |
Method Description
Carboxy tetrahydrocannabinol (THC-COOH) is extracted from urine by making the urine alkaline to hydrolyze THC-COOH glucuronide. The hydrolyzed samples are diluted for analysis by liquid chromatography tandem mass spectrometry using selected ion monitoring.(Unpublished Mayo method)
Report Available
3 to 5 daysReject Due To
| Gross hemolysis | OK |
| Gross icterus | Reject |
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-General Request (T239)
-Therapeutics Test Request (T831)
Aliases: Cannabinoids, J (Jane), Jane, Marijuana, Mary Jane, Tetrahydrocannabinol (THC) Confirmation, Quantitative, Urine, Tetrahydrocannabinol, QN, THC, Urine THC Quantitation, U THC QNT