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Test Code LAB5026 COVID-19 Antibody, Nucleocapsid IgG

Additional Codes

COVID Nucleo

Synonyms

2019-nCoV; Coronavirus; COVID; COVID-19; COVID19; COVID-19 Antibody (IgG); Covid-19 IgG; nCoV; NCVIGG; SARS; SARS-CoV-2

Description

The Abbott Architect SARS-CoV-2 IgG assay, run under an emergency use authorization from the FDA, is a qualitative test designed to detect IgG antibodies to the nucleocapsid protein of SARS-CoV-2 in serum and plasma from patients who are suspected of past coronavirus disease (COVID-19) or in serum and plasma of subjects that may have been infected by SARS-CoV-2.

 

Assay Notes:

  • This assay detects response to nucleocapsid, the vaccines induce responses to the spike protein, therefore the currently available Abbott SARS-CoV-2 IgG immunoassay will not detect response to vaccine.
  • However, the newer Abbott SARS-CoV-2 IgG II immunoassay does detect antibodies to the spike protein of SARS-CoV-2.  This assay is orderable as COVID-19 Antibody, Spike IgG (LAB3719). This immunoassay will detect response to vaccine, as well as past infection.

Clinical Information

  • Serological testing is NOT indicated for diagnosis of acute infection and should not be ordered while a patient is being investigated for active SARS-CoV-2 infection.
  • Samples should be collected at least 21 days after onset of symptoms, to avoid potential false negative results.
  • Clinical indication for testing is limited to patients with COVID-19 like symptoms who tested negative by PCR or who were not tested.  
  • Please refer to these FAQs.

Sample Requirements

Specimen: Whole Blood

Container(s): Gold, Gold Microtainer, Red Top-Plain, or Lavender Top Tube

Preferred Vol: 5.0 mL

Minimum Vol: 1.0 mL

 

Note: 

Processing Instructions

Reject due to:

Spin: Y

Aliquot: Y

Temp: 2 - 8°C

Storage Location: CPA1 Refrigerator, UW/HMC Send Outs rack.

Off-site Collection: Spin within 24 hours and aliquot 2.5 mL (Min. 0.5 mL) serum or plasma into a plastic aliquot tube. Send specimen refrigerated.

Stability

Specimen Type Temperature Time
Serum or Plasma Room Temp 24 h
  Refrigerated 7 d
  Frozen Indefinite

 

Availability

STAT Performed TAT
N M & F 24 - 72 h

Performing Laboratory

University of Washington

Department of Laboratory Medicine

Virology-COVID Testing Lab, Renton

1601 Lind Ave SW

Renton, WA 98057

 

Phone Number: (206) 520-4600

Department

Department: Send Outs

Phone Number: (206) 987-2563

CPT Codes

86769

Reference Range

Interpretation
Nonreactive (Negative)
Reactive (Positive)

Methodology

Method: Chemiluminescentce

Analytical Volume: 0.5 mL Serum or Plasma

Send Out Instructions

Reference Lab Test Name: SARS CoV 2 Nucleocapsid Antibody, IgG
Reference Lab Test Code:

NCVIGG
Instructions:

Send out daily with the UW courier.