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HelpTest Code LAB62 Creatine Kinase
Clinical System Name
Creatine Kinase
Synonyms
LAB 62
CK
CPK (Creatine Phosphokinase)
Sample Requirements
Specimen: Whole Blood
Container(s): Lt. Green/Mint Top Lithium Heparin, Lt. Green/Lithium Heparin Microtainer, Gold SST, Gold Microtainer, Dark Green/Sodium Heparin, Red
Preferred Vol: 1.0 mL
Minimum Vol: 0.5 mL
Note: Method is affected by EDTA, hemolysis, and prolonged exposure to RBC's. Not affected by lipemia.
Processing Instructions
Reject due to: Age of specimen, hemolysis, incorrect specimen type
Spin: Y
Aliquot: Y
Storage Location: Core 5 Chemistry Refrigerator
Off-Site Collection: Avoid hemolysis. Specimen should be centrifuged within 2 hours of collection. Spin blood and transfer serum or plasma to plastic tube and refrigerate or freeze.
Stability
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum or Plasma | RT |
≤ 4 h |
| Serum or Plasma | 2-8 C |
≤ 5 d |
| Serum or Plasma | -20 C or -70 C |
≤ 30 d |
Availability
| STAT | Performed | TAT |
|---|---|---|
| Y | 24/7 | 1 h |
Performing Laboratory
Seattle Children's Laboratory
Department
Department: Core Chemistry
Phone Number: 206-987-2617 (Client Services)
CPT Codes
82550
Methodology
Method: Multiple Point Rate by Vitros 4600
Analytical Volume: 0.02 mL + 0.03 mL dead space
Reference Range
| Age | IU/L At 37° C |
| 0 - 3 W | 0 - 600 |
| 3 W- 3 M | 0 - 440 |
| > 3 M (Male) | 35 - 230 |
| > 3 M (Female) | 20 - 215 |
Description
Serum CK is almost always increased following acute myocardial infarction or skeletal muscle damage. CK is commonly elevated in myocarditis of any cause, cerebrovascular accidents, rhabdomyolysis, polymyositis, muscular dystrophies (Duchenne’s may have an elevation of 20-200 times normal levels), and acute physical exertion. Low CK may reflect decreased muscle mass, advanced malignancy, or muscle wasting.