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Test Code LAB720 17-Hydroxyprogesterone

Clinical System Name

17-OH-Progesterone

Synonyms

17 OHP

17OHP

Sample Requirements

Specimen: Whole blood

Container(s): Gold SST Microtainer, Red

Preferred Vol: 2 mL

Minimum Vol: 1 mL

 

Note:

 

Processing Instructions

Reject due to: 

Spin: Y

Aliquot: Y

Temp: -20 C

Storage location: Transfer 200 mcL serum to plastic aliquot container affixed with larger Epic label. Freeze in CPA Freezer, Fz6 rack. Store label with specimen.

 

Off-site collection: Spin blood, transfer serum to plastic aliquot container. Freeze specimen.

Stability

Specimen Type Temperature Time
Serum  Room temp 2 h
  Refrigerated 1 m
  Frozen 6 m

 

Availability

STAT Performed TAT
N T, Th 2 - 6 d

 

Contact Chemistry Lab for request outside of stated availability. (206) 987-2565

Performing Laboratory

Seattle Children's Laboratory    

 

Department

Department:  Chemistry

Location: Chem West

Phone Number: (206) 987-2617

 

 

 

CPT Codes

83498

Methodology

Method: Liquid chromatography tandem mass spectrometry (LC-MS/MS)

Analytical Volume: 200 mcL serum or plasma

Limitations:

Reference Range

Age Female (ng/dL) Male (ng/dL)
1 - 3 days (full-term) 7 - 77 7 - 77
4 days - 2 months Does not apply Less than 200
4 days - 5 months 7 - 106  
3 - 5 months Does not apply 3 - 90
6 months - 1 year Less than 148 Less than 148
2 - 3 years Less than 256 Less than 228
4 - 6 years Less than 299 Less than 208
7 - 9 years Less than 71 Less than 63
10 - 12 years Less than 129 Less than 79
13 - 15 years 9 - 208 9 - 140
16 - 17 years Less than 178 24 - 192
18 years and older Less than 207 Less than 139
Tanner Stage I Less than 74 Less than 62
Tanner Stage II Less than 164 Less than 104
Tanner Stage III 13 - 209 Less than 151
Tanner Stage IV-V 7 - 170 20 - 173

 

Clinical Information

17α-hydroxyprogesterone (17-OHP) is the best screening test for congenital adrenal hyperplasia (CAH), caused by either 11- or 21-hydroxylase deficiency. Analysis of 17-OHP is also useful for evaluation of hirsutism or infertility in females, both as a result from adult-onset of CAH.

While classic, infantile presentations generally have 17-OHP concentrations in the thousands, results between 200-1000 ng/dL could be indicative of late onset congenital adrenal hyperplasia.