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HelpTest Code LAB872 Deamidated Gliadin Peptide, IgG (DGP)
Clinical System Name
Gliadin (Deamidated) Ab, IgG
Synonyms
DAGL
Gliad Ab
DGP
DGP IgG
Sample Requirements
Specimen: Whole blood
Container(s): Gold SST Microtainer, Red
Preferred Vol: 1 mL
Minimum Vol: 0.5 mL
Note:
Processing Instructions
Reject due to:
Spin: Y
Aliquot: Y
Temp: 2-8 C
Storage location: Transfer to plastic aliquot container affixed with larger Epic label. Refrigerate in CPA, FrigF rack.
Off-site collection: Spin blood, transfer serum to plastic aliquot container. Refrigerate specimen.
Stability
| Specimen Type | Temperature | Time |
|---|---|---|
| separated serum | Room temp | |
| Refrigerated | 7 d | |
| Frozen | 8 m |
Availability
| STAT | Performed | TAT |
|---|---|---|
| N | M-F | 1-3 d |
Performing Laboratory
Seattle Children's Laboratory
Department
Department: Chemistry
Location: Chem East
Phone Number: (206) 987-3694
CPT Codes
86258
Methodology
Method: Immunoassay on Bioplex 2200
Analytical Volume: 100 mcL serum
Limitations:
Reference Range
| Units/mL | |
|---|---|
| Negative | < 15 |
| Positive | > 15 |
Description
This test is used in the diagnosis and monitoring of patients with Celiac Disease. It measures the IgG isotypes of the gliadin protein after it has been selectively deamidated by tissue transglutaminase. Studies have shown that the sensitivity and specificity of DGP, IgA and IgG for celiac disease are comparable to tissue transglutaminase, and higher than that of endomysial antibodies (EMA). In addition to tTG-IgA, DGP is recommended in place of EMA for IgA deficient patients (2% of our population), for patients in whom a second test is desired based on clinical history, and in patients less than two years of age.